nevirapine will decrease the extent or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
It is not identified no matter if this medicine will hurt an unborn newborn. Inform your physician If you're pregnant or approach to be pregnant.
enasidenib will increase the level or impact of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Enasidenib (a weak CYP2C19 inhibitor) could raise systemic publicity of delicate CYP2C19 substrates. Watch and change dose of substrate as clinically indicated.
modafinil will enhance the level or impact of diazepam buccal by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Sturdy or reasonable CYP2C19 inhibitors may well lower fee of diazepam elimination, thereby rising adverse reactions to diazepam.
Modafinil appeared to make a focus-related suppression of CYP2C9 action, for that reason suggesting probable for CYP2C9 inhibition; warning if medicine which have a slim therapeutic index
Even though the consequences of modafinil are comparable to People of amphetamines like Adderall, it’s an extremely various material. Modafinil is actually a eugeroic that precisely improves alertness, whilst Adderall and various amphetamines are psychostimulants that generate A short lived boost in All round psychomotor exercise.
This drugs might impair your considering or reactions. Watch out for those who travel or do just about anything that requires you to be warn.
If you take modafinil to assist with obstructive sleep apnea, it can be crucial to carry on your other prescribed snooze apnea treatment plans, which include employing a continual optimistic airway strain (CPAP) device, Except if your healthcare company informs you never to.
modafinil will raise the amount or result of mavacamten by influencing hepatic enzyme CYP2C19 metabolism. Contraindicated. Solid or moderate CYP2C19 inhibitors click here may possibly maximize mavacamten systemic exposure, leading to heart failure as a consequence of systolic dysfunction.
There might be other Uncomfortable side effects of modafinil that are not outlined right here. Get in touch with your Health care supplier if you think you might be having a aspect effect of the medicine.
Clopidogrel efficacy could possibly be decreased by medicines that inhibit CYP2C19. Inhibition of platelet aggregation by clopidogrel is completely because of an active metabolite. Clopidogrel is metabolized to this Lively metabolite partially by CYP2C19. .
In contrast to amphetamine together with other central anxious stimulants that induce wakefulness by common common neuronal activation, modafinil activates neurons selectively, concentrating primarily on the hypothalamus and amygdala.
As typical, either side of the story are very important. There’s no denying the many years of exploration that have irrefutably proven that modafinil has remarkable cognitive Gains and reduced dependancy probable.
Modafinil is a regulated drug that is definitely permitted to be used only as a treatment for specific Problems, so there isn't any Formal recommendation for dosage when it's used off-label as being a nootropic. Many buyers report exceptional effects with dosages amongst 50–200 mg day by day.[36]